Effects of a 1,2,4-triazole derivative liposome emulsion on the innate and adaptive immunity of puppies vaccinated against canine parvovirus and canine distemper

Abstract

The aim of the study was the evaluate the immunomodulating effect of a 1,2,4-triazole derivative liposome emulsion (Trifuzol) in puppies vaccinated against parvovirus enteritis and canine distemper. The used Trifuzol liposome emulsion led to a significant increase in the absolute number of lymphocytes and their immunoregulatory subpopulations, phagocytic activity of neutrophils. The level of antibodies against parvovirus enteritis (CPV) and canine distemper (CDV) in vaccinated and Trifuzol-treated puppies reached zero values which were statistically significantly lower than those in vaccinated-only puppies (21.0 U/mL and 27.0 U/mL, respectively). It was concluded that the tested liposome emulsion of Trifuzol had an positive effect on the humoral immunity in puppies and can be used in clinical practice as an immunomodulatory agent.

Keywords

• absolute lymphocyte count
• neutrophil phagocytosis
• puppies
• specific IgG antibodies titre
• vaccination