Infection and Drug Resistance (Apr 2024)

Clinical Characteristics and Analysis of Associated Risk Factors in Patients with Severe and Non-Severe COVID-19 Infection

  • Zhou Y,
  • Wang Z,
  • Chen F,
  • Xiong YX,
  • Wang W,
  • Huang JM,
  • Fang W

Journal volume & issue
Vol. Volume 17
pp. 1539 – 1544

Abstract

Read online

Yong Zhou, Zhen Wang, Fei Chen, Ying-Xia Xiong, Wei Wang, Jun-Min Huang, Wei Fang Department of Emergency, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, People’s Republic of ChinaCorrespondence: Zhen Wang, Department of Emergency, Beijing Shijitan Hospital, Capital Medical University, No. 10 Tieyi Road, Yangfangdian, Haidian District, Beijing, 100038, People’s Republic of China, Tel +86 10 63926250, Fax +86 10 63925651, Email [email protected]: Our aim was to highlight the clinical characteristics and determine the risk factors associated with severe and non-severe COVID-19 infection.Study Method: A retrospective review was conducted on clinical data obtained from patients with COVID-19 infection, admitted to the emergency department between November 2022 and January 2023. Total of 1684 participants were categorized into severe (312 cases,18.53%) and non-severe (1,372 cases,81.47%) cohorts. Logistic regression was utilized for multivariate analysis, with a P-value less than 0.05 signifying a significant difference between the groups.Results: The study consisted of 952 males (56.53%) and 732 females (43.47%) participants. The age distribution ranged from 18 to 93 years in both cohorts. There were statistically significant differences between the clinical symptoms of the severe and non-severe cohorts (P < 0.05). According to the multivariate statistical analysis, patients with more pronounced clinical manifestations had significantly elevated values related to age(P < 0.05), diabetes(P < 0.01), hypertension(P < 0.01), C-reactive protein (CRP) (P < 0.05), and lactate dehydrogenase (LDH) (P < 0.01) as compared to those presenting with milder symptoms.Conclusion: The primary clinical presentations in both the cohorts were mostly similar. Predominant factors contributing to the severity of COVID-19 infection were age, diabetes, hypertension, elevated CRP levels, and increased LDH.Keywords: clinical manifestations, COVID-19, risk factors

Keywords