Association between the oxidative balance score and estimated glomerular filtration rate: 2007–2018 NHANES
Mingda Wu,
Cuiting Dong,
Zhen Yang,
Yongfu Song,
Chenkai Xu,
Shuang Ma,
Yuejiao Lan,
Xiaodan Lu
Affiliations
Mingda Wu
Precision Medicine Center, Jilin Province People’s Hospital, Changchun, Jilin, 130021, China
Cuiting Dong
Changchun University of Chinese Medicine, Changchun, Jilin, 130021, China
Zhen Yang
Changchun University of Chinese Medicine, Changchun, Jilin, 130021, China
Yongfu Song
Department of Pediatrics, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin, China
Chenkai Xu
Changchun University of Chinese Medicine, Changchun, Jilin, 130021, China
Shuang Ma
Precision Medicine Center, Jilin Province People’s Hospital, Changchun, Jilin, 130021, China
Yuejiao Lan
Precision Medicine Center, Jilin Province People’s Hospital, Changchun, Jilin, 130021, China; Corresponding author. Precision Medicine Center, Jilin Province People’s Hospital, Changchun, Jilin, 130021, China.
Xiaodan Lu
Precision Medicine Center, Jilin Province People’s Hospital, Changchun, Jilin, 130021, China; Changchun University of Chinese Medicine, Changchun, Jilin, 130021, China; Corresponding author. Precision Medicine Center, Jilin Province People’s Hospital, Changchun, Jilin, 130021, China.
Oxidative stress is closely associated with the estimated glomerular filtration rate (eGFR) levels. A comprehensive indicator for evaluating dietary and lifestyle exposures to oxidative stress is the Oxidative Balance Score (OBS), with higher OBS suggesting more substantial antioxidant exposures. The aim of this study is to explore the relationship between OBS and eGFR levels. A total of 20,285 subjects were selected from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018. One-way and multifactorial linear regression analyses were used to assess the association of OBS with eGFR. The relationship between OBS and eGFR levels was also assessed using restricted cubic splines (RCS) analysis. OBS levels were significantly and positively correlated with eGFR levels, and eGFR values were more susceptible to OBS in males than in females. Our findings suggest that higher OBS scores may be associated with higher eGFR levels, highlighting the importance of adhering to an antioxidant diet and lifestyle, which can help prevent kidney disease.
