Communications Biology (Jul 2021)

HLA-B and cysteinylated ligands distinguish the antigen presentation landscape of extracellular vesicles

  • Julia Bauzá-Martinez,
  • Albert J. R. Heck,
  • Wei Wu

DOI
https://doi.org/10.1038/s42003-021-02364-y
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 11

Abstract

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Bauzá-Martinez et al. analyzed the HLA-I peptide ligandome in extracellular vesicles (EVs) from an EBV-immortalized B cell line, JY, and compare HLA-I-binding peptides recovered from EVs to those recovered from whole-cells. The authors report an enrichment for HLA-B-binding peptides and for post-translationally modified cysteinylated peptides in EVs as compared to whole-cells.