Nature Communications (Jan 2017)
A non-canonical mismatch repair pathway in prokaryotes
- A. Castañeda-García,
- A. I. Prieto,
- J. Rodríguez-Beltrán,
- N. Alonso,
- D. Cantillon,
- C. Costas,
- L. Pérez-Lago,
- E. D. Zegeye,
- M. Herranz,
- P. Plociński,
- T. Tonjum,
- D. García de Viedma,
- M. Paget,
- S. J. Waddell,
- A. M. Rojas,
- A. J. Doherty,
- J. Blázquez
Affiliations
- A. Castañeda-García
- Stress and Bacterial Evolution Group, Instituto de Biomedicina de Sevilla. Avda. Manuel Siurot S/N
- A. I. Prieto
- Stress and Bacterial Evolution Group, Instituto de Biomedicina de Sevilla. Avda. Manuel Siurot S/N
- J. Rodríguez-Beltrán
- Stress and Bacterial Evolution Group, Instituto de Biomedicina de Sevilla. Avda. Manuel Siurot S/N
- N. Alonso
- Centro Nacional de Biotecnología-CSIC. C/ Darwin 3
- D. Cantillon
- Brighton and Sussex Medical School, University of Sussex
- C. Costas
- Stress and Bacterial Evolution Group, Instituto de Biomedicina de Sevilla. Avda. Manuel Siurot S/N
- L. Pérez-Lago
- Servicio de Microbiología Clínica y Enfermedades Infecciosas, Hospital Gregorio Marañón and Instituto de Investigación Sanitaria Gregorio Marañón. Dr. Esquerdo 46
- E. D. Zegeye
- Department of Microbiology, Norway and Department of Microbiology, Oslo University Hospital, Rikshospitalet, Oslo, University of Oslo
- M. Herranz
- Servicio de Microbiología Clínica y Enfermedades Infecciosas, Hospital Gregorio Marañón and Instituto de Investigación Sanitaria Gregorio Marañón. Dr. Esquerdo 46
- P. Plociński
- Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
- T. Tonjum
- Department of Microbiology, Norway and Department of Microbiology, Oslo University Hospital, Rikshospitalet, Oslo, University of Oslo
- D. García de Viedma
- Servicio de Microbiología Clínica y Enfermedades Infecciosas, Hospital Gregorio Marañón and Instituto de Investigación Sanitaria Gregorio Marañón. Dr. Esquerdo 46
- M. Paget
- School of Life Sciences, University of Sussex
- S. J. Waddell
- Brighton and Sussex Medical School, University of Sussex
- A. M. Rojas
- Computational Biology and Bioinformatics, Instituto de Biomedicina de Sevilla (IBIS)-CSIC. Avda. Manuel Siurot S/N
- A. J. Doherty
- Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
- J. Blázquez
- Stress and Bacterial Evolution Group, Instituto de Biomedicina de Sevilla. Avda. Manuel Siurot S/N
- DOI
- https://doi.org/10.1038/ncomms14246
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Despite the importance of mismatch repair for genome stability, many Archaea and almost all Actinobacteria lack MutS and MutL proteins. Here the authors, usingMycobacterium smegmatisas a model, report that NucS/EndoMS endonuclease acts in a distinct mismatch repair pathway.
