Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents
Mariusz Skwarczynski,
Sahra Bashiri,
Ye Yuan,
Zyta M. Ziora,
Osama Nabil,
Keita Masuda,
Mattaka Khongkow,
Natchanon Rimsueb,
Horacio Cabral,
Uracha Ruktanonchai,
Mark A. T. Blaskovich,
Istvan Toth
Affiliations
Mariusz Skwarczynski
School of Chemistry and Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
Sahra Bashiri
School of Chemistry and Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
Ye Yuan
Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
Zyta M. Ziora
Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
Osama Nabil
Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
Keita Masuda
Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
Mattaka Khongkow
National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong 1, Klong Luang 12120, Pathumthani, Thailand
Natchanon Rimsueb
National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong 1, Klong Luang 12120, Pathumthani, Thailand
Horacio Cabral
Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
Uracha Ruktanonchai
National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong 1, Klong Luang 12120, Pathumthani, Thailand
Mark A. T. Blaskovich
Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
Istvan Toth
School of Chemistry and Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
The development of effective treatments against infectious diseases is an extensive and ongoing process due to the rapid adaptation of bacteria to antibiotic-based therapies. However, appropriately designed activity enhancers, including antibiotic delivery systems, can increase the effectiveness of current antibiotics, overcoming antimicrobial resistance and decreasing the chance of contributing to further bacterial resistance. The activity/delivery enhancers improve drug absorption, allow targeted antibiotic delivery, improve their tissue and biofilm penetration and reduce side effects. This review provides insights into various antibiotic activity enhancers, including polymer, lipid, and silver-based systems, designed to reduce the adverse effects of antibiotics and improve formulation stability and efficacy against multidrug-resistant bacteria.
