Preclinical study of the toxicity of the oral form of pegylated interferon α-2b under its long-term use

Abstract

The aim of the study is to investigate the chronic toxicity of the oral finished dosage form of pegylated interferon α-2b, obtained with the help of electron-beam synthesis technology. Materials and methods. The preparation was orally administered to rats and rabbits at the calculated therapeutic doses and doses exceeding them. The drug effect on the general condition and body weight, hematological parameters, myelogram, blood biochemical parameters, excretory and cardiovascular system, CNS were studied. As well as pathomorphological examination was carried out. Results and discussion. The drug has no toxic and locally irritating effect under its long-term use per os.

Keywords

• interferon α-2b
• pegylation
• electron-beam immobilization
• chronic toxicity
• preclinical trials