Effect of glucocorticoid treatment on ovarian morphology and function in experimental autoimmune oophoritis

Abstract

The effect of glucocorticoids (GC) on the character and dynamics of changes in various tissue elements of the ovaries were studied in an experimental model of autoimmune oophoritis using histological and histochemical techniques. The content of antiovarian antibodies (AOA) was determined in the serum of experimental animals by enzyme immunoassay. Not enough effective action of GC therapy was found on the immediate and long-term results. Dynamic decrease of AOA and normalization of the specific volumes of the generative elements were accompanied by increased follicular atresia. Most of the generative structures were destructively modified.

Keywords

• аутоиммунный оофорит
• глюкокортикоидная терапия
• антиовариальные антитела
• морфология