Revista de la Sociedad Argentina de Diabetes (Jul 2018)

TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE

  • Susana Gutt,
  • María Álvarez,
  • María Yuma,
  • Marianela Ackermann,
  • María Coronel,
  • Carla Gauna,
  • Sandra González,
  • Paula Lifszyc,
  • Estrella Menéndez,
  • Juliana Mociulsky,
  • Carla Musso,
  • Paola Polo,
  • Victoria Salinas,
  • Guadalupe Vanoli,
  • Susana Fuentes

DOI
https://doi.org/10.47196/diab.v52i1.80
Journal volume & issue
Vol. 52, no. 1
pp. 10 – 24

Abstract

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Nonalcoholic fatty liver disease (NAFLD) is a fatty disease of the liver that is not associated with alcohol. Its prevalence increases along with the epidemic of obesity and type 2 diabetes, and the risk of suffering a more aggressive liver disease is greater with the consequent increase in cirrhosis, hepatocellular carcinoma and cardiovascular disease (CVD). The ectopic accumulation of fat is associated with high-fat diets and high energy density, hyperglycemia and insulin resistance that lead to the suppression of hepatic glucose production and decreased glucose uptake by the skeletal muscle which promotes the lipogenesis of novo and generates a vicious circle that favors even more steatosis.

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