Diagnostics (Jan 2023)

Thyroid Collision Tumors: The Presence of the Medullary Thyroid Carcinoma Component Negatively Influences the Prognosis

  • Ion Negura,
  • Victor Ianole,
  • Mihai Danciu,
  • Cristina Preda,
  • Diana Gabriela Iosep,
  • Radu Dănilă,
  • Alexandru Grigorovici,
  • Delia Gabriela Ciobanu Apostol

DOI
https://doi.org/10.3390/diagnostics13020285
Journal volume & issue
Vol. 13, no. 2
p. 285

Abstract

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Thyroid collision tumors (TCTs) are rare pathological findings, representing p = 0.000), lymphovascular invasion (LVI) (p = 0.000), perineural invasion (PNI) (p = 0.044), and lymph node metastasis (p = 0.042). Additionally, the TCTs’ MTC component presented with more frequent LVI (p = 0.010). Comparing TCTs’ MTC and PTC components with MTC-only tumors and PTC-only tumors revealed that only the TCTs’ MTC components had statistically significant more frequent mETE (p = 0.010) than MTC-only tumors. When applied to the MTC component of TCTs, the pathological parameters of the new grading system of MTC showed no correlations with other microscopic or clinical aspects. Conclusion: Using classical pathological prognostic features, the comparative analysis revealed that the main TCTs’ component was more aggressive than the minor one. Contrary to PTCs, in TCTs, the medullary component was more aggressive than the papillary one, but also more aggressive than MTC-only tumors.

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