Communications Biology (Dec 2022)

DNA methylation and hydroxymethylation characterize the identity of D1 and D2 striatal projection neurons

  • Lucile Marion-Poll,
  • Jean-Pierre Roussarie,
  • Lieng Taing,
  • Cloelia Dard-Dascot,
  • Nicolas Servant,
  • Yan Jaszczyszyn,
  • Emmanuelle Jordi,
  • Eskeatnaf Mulugeta,
  • Denis Hervé,
  • Déborah Bourc’his,
  • Paul Greengard,
  • Claude Thermes,
  • Jean-Antoine Girault

DOI
https://doi.org/10.1038/s42003-022-04269-w
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 16

Abstract

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Striatal projection neurons expressing the D1 or D2 dopamine receptors are probed for translating mRNAs and DNA modifications, identifying differential methylation signatures between the cell types and genome-wide hydroxymethylation asymmetry between the two DNA strands.