Journal of Clinical Medicine (Dec 2021)
ICU-Acquired Pneumonia Is Associated with Poor Health Post-COVID-19 Syndrome
- Ignacio Martin-Loeches,
- Anna Motos,
- Rosario Menéndez,
- Albert Gabarrús,
- Jessica González,
- Laia Fernández-Barat,
- Adrián Ceccato,
- Raquel Pérez-Arnal,
- Dario García-Gasulla,
- Ricard Ferrer,
- Jordi Riera,
- José Ángel Lorente,
- Óscar Peñuelas,
- Jesús F. Bermejo-Martin,
- David de Gonzalo-Calvo,
- Alejandro Rodríguez,
- Ferran Barbé,
- Luciano Aguilera,
- Rosario Amaya-Villar,
- Carme Barberà,
- José Barberán,
- Aaron Blandino Ortiz,
- Elena Bustamante-Munguira,
- Jesús Caballero,
- Cristina Carbajales,
- Nieves Carbonell,
- Mercedes Catalán-González,
- Cristóbal Galbán,
- Víctor D. Gumucio-Sanguino,
- Maria del Carmen de la Torre,
- Emili Díaz,
- Elena Gallego,
- José Luis García Garmendia,
- José Garnacho-Montero,
- José M. Gómez,
- Ruth Noemí Jorge García,
- Ana Loza-Vázquez,
- Judith Marín-Corral,
- Amalia Martínez de la Gándara,
- Ignacio Martínez Varela,
- Juan Lopez Messa,
- Guillermo M. Albaiceta,
- Mariana Andrea Novo,
- Yhivian Peñasco,
- Pilar Ricart,
- Luis Urrelo-Cerrón,
- Angel Sánchez-Miralles,
- Susana Sancho Chinesta,
- Lorenzo Socias,
- Jordi Solé-Violan,
- Luis Tamayo Lomas,
- Pablo Vidal,
- Antoni Torres
Affiliations
- Ignacio Martin-Loeches
- CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, 28029 Madrid, Spain
- Anna Motos
- CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, 28029 Madrid, Spain
- Rosario Menéndez
- CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, 28029 Madrid, Spain
- Albert Gabarrús
- CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, 28029 Madrid, Spain
- Jessica González
- Translational Research in Respiratory Medicine Group (TRRM), Lleida Biomedical Research Institute (IRBLleida), 25198 Lleida, Spain
- Laia Fernández-Barat
- CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, 28029 Madrid, Spain
- Adrián Ceccato
- CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, 28029 Madrid, Spain
- Raquel Pérez-Arnal
- Barcelona Supercomputing Centre (BSC), 08034 Barcelona, Spain
- Dario García-Gasulla
- Barcelona Supercomputing Centre (BSC), 08034 Barcelona, Spain
- Ricard Ferrer
- CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, 28029 Madrid, Spain
- Jordi Riera
- CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, 28029 Madrid, Spain
- José Ángel Lorente
- CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, 28029 Madrid, Spain
- Óscar Peñuelas
- CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, 28029 Madrid, Spain
- Jesús F. Bermejo-Martin
- CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, 28029 Madrid, Spain
- David de Gonzalo-Calvo
- Translational Research in Respiratory Medicine Group (TRRM), Lleida Biomedical Research Institute (IRBLleida), 25198 Lleida, Spain
- Alejandro Rodríguez
- Critical Care Department, Hospital Joan XXIII, 43005 Tarragona, Spain
- Ferran Barbé
- Translational Research in Respiratory Medicine Group (TRRM), Lleida Biomedical Research Institute (IRBLleida), 25198 Lleida, Spain
- Luciano Aguilera
- Anestesia, Reanimación y Terapia del Dolor, Hospital Universitario de Basurto, 48013 Bilbao, Spain
- Rosario Amaya-Villar
- Intensive Care Clinical Unit, Hospital Universitario Virgen de Rocío, 41013 Sevilla, Spain
- Carme Barberà
- Hospital Santa Maria, IRBLleida, 25198 Lleida, Spain
- José Barberán
- Critical Care Department, Hospital Universitario HM Montepríncipe, Universidad San Pablo-CEU, 28660 Madrid, Spain
- Aaron Blandino Ortiz
- Servicio de Medicina Intensiva, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain
- Elena Bustamante-Munguira
- Department of Intensive Care Medicine, Hospital Clínico Universitario Valladolid, 47003 Valladolid, Spain
- Jesús Caballero
- Critical Care Department, Hospital Universitari Arnau de Vilanova, IRBLleida, 25198 Lleida, Spain
- Cristina Carbajales
- Hospital Álvaro Cunqueiro, 36213 Vigo, Spain
- Nieves Carbonell
- Intensive Care Unit, Hospital Clínico y Universitario de Valencia, 46010 Valencia, Spain
- Mercedes Catalán-González
- Department of Intensive Care Medicine, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain
- Cristóbal Galbán
- Department of Medicine, CHUS, Complejo Hospitalario Universitario de Santiago, 15076 Santiago de Compostela, Spain
- Víctor D. Gumucio-Sanguino
- Department of Intensive Care, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, 08907 Barcelona, Spain
- Maria del Carmen de la Torre
- Hospital de Mataró de Barcelona, 08301 Mataró, Spain
- Emili Díaz
- Department of Medicine, Universitat Autònoma de Barcelona (UAB), Critical Care Department, Corpo-Ració Sanitària Parc Taulí, Sabadell, 08208 Barcelona, Spain
- Elena Gallego
- Unidad de Cuidados Intensivos, Hospital San Pedro de Alcántara, 10003 Cáceres, Spain
- José Luis García Garmendia
- Intensive Care Unit, Hospital San Juan de Dios del Aljarafe, 41930 Sevilla, Spain
- José Garnacho-Montero
- Intensive Care Clinical Unit, Hospital Universitario Virgen Macarena, 41009 Seville, Spain
- José M. Gómez
- Hospital General Universitario Gregorio Marañón, 28009 Madrid, Spain
- Ruth Noemí Jorge García
- Intensive Care Department, Hospital Nuestra Señora de Gracia, 50009 Zaragoza, Spain
- Ana Loza-Vázquez
- Unidad de Medicina Intensiva, Hospital Universitario Virgen de Valme, 41014 Sevilla, Spain
- Judith Marín-Corral
- Critical Care Department, Hospital del Mar-IMIM, 08003 Barcelona, Spain
- Amalia Martínez de la Gándara
- Department of Intensive Medicine, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain
- Ignacio Martínez Varela
- Critical Care Department, Hospital Universitario Lucus Augusti, 27003 Lugo, Spain
- Juan Lopez Messa
- Critical Care Department, Complejo Asistencial Universitario de Palencia, 34005 Palencia, Spain
- Guillermo M. Albaiceta
- Departamento de Biología Funcional, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, 33011 Oviedo, Spain
- Mariana Andrea Novo
- Servei de Medicina Intensiva, Hospital Universitari Son Espases, Palma de Mallorca, 07120 Illes Balears, Spain
- Yhivian Peñasco
- Servicio de Medicina Intensiva, Hospital Universitario Marqués de Valdecilla, 39008 Santander, Spain
- Pilar Ricart
- Servei de Medicina Intensiva, Hospital Universitari Germans Trias, 08916 Badalona, Spain
- Luis Urrelo-Cerrón
- Hospital Verge de la Cinta, 08916 Tortosa, Spain
- Angel Sánchez-Miralles
- Hospital de Sant Joan d’Alacant, 03550 Alacant, Spain
- Susana Sancho Chinesta
- Servicio de Medicina Intensiva, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain
- Lorenzo Socias
- Intensive Care Unit, Hospital Son Llàtzer, Palma de Mallorca, 07198 Illes Balears, Spain
- Jordi Solé-Violan
- CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, 28029 Madrid, Spain
- Luis Tamayo Lomas
- Critical Care Department, Hospital Universitario Río Hortega de Valladolid, 47102 Valladolid, Spain
- Pablo Vidal
- Intensive Care Unit, Complexo Hospitalario Universitario de Ourense, 32005 Ourense, Spain
- Antoni Torres
- CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, 28029 Madrid, Spain
- DOI
- https://doi.org/10.3390/jcm11010224
- Journal volume & issue
-
Vol. 11,
no. 1
p. 224
Abstract
Background. Some patients previously presenting with COVID-19 have been reported to develop persistent COVID-19 symptoms. While this information has been adequately recognised and extensively published with respect to non-critically ill patients, less is known about the incidence and factors associated with the characteristics of persistent COVID-19. On the other hand, these patients very often have intensive care unit-acquired pneumonia (ICUAP). A second infectious hit after COVID increases the length of ICU stay and mechanical ventilation and could have an influence on poor health post-COVID 19 syndrome in ICU-discharged patients. Methods: This prospective, multicentre, and observational study was carrid out across 40 selected ICUs in Spain. Consecutive patients with COVID-19 requiring ICU admission were recruited and evaluated three months after hospital discharge. Results: A total of 1255 ICU patients were scheduled to be followed up at 3 months; however, the final cohort comprised 991 (78.9%) patients. A total of 315 patients developed ICUAP (97% of them had ventilated ICUAP). Patients requiring invasive mechanical ventilation had more persistent post-COVID-19 symptoms than those who did not require mechanical ventilation. Female sex, duration of ICU stay, development of ICUAP, and ARDS were independent factors for persistent poor health post-COVID-19. Conclusions: Persistent post-COVID-19 symptoms occurred in more than two-thirds of patients. Female sex, duration of ICU stay, development of ICUAP, and ARDS all comprised independent factors for persistent poor health post-COVID-19. Prevention of ICUAP could have beneficial effects in poor health post-COVID-19.
Keywords