Research Progress on Molecular Changes in Pulmonary Hypoxia and Cause of Death Identification in Mechanical Asphyxia
WU Tian-pu,
MA Jian-long,
LIAO Xin-biao,
ZHANG Dong-chuan,
MA Kai-jun,
YU Yan-geng,
CHEN Long
Affiliations
WU Tian-pu
Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
MA Jian-long
Institute of Criminal Science and Technology, Investigation Department of Shenzhen Public Security Bureau, Key Laboratory of Forensic Pathology, Ministry of Public Security, Shenzhen 518040, Guangdong Province, China
LIAO Xin-biao
Institute of Forensic Science, Guangdong Provincial Public Security Department, Key Laboratory of Forensic Pathology, Ministry of Public Security, Guangzhou 510050, China
ZHANG Dong-chuan
Shanghai Key Laboratory of Crime Scene Evidence, Institute of Forensic Science, Shanghai Municipal Public Security Bureau, Shanghai 200083, China
MA Kai-jun
Shanghai Key Laboratory of Crime Scene Evidence, Institute of Forensic Science, Shanghai Municipal Public Security Bureau, Shanghai 200083, China
YU Yan-geng
Institute of Forensic Science, Guangdong Provincial Public Security Department, Key Laboratory of Forensic Pathology, Ministry of Public Security, Guangzhou 510050, China
CHEN Long
Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
Lung is the largest organ of the respiratory system. During hypoxia, pulmonary cells undergo rapid damage changes and activate the self-rescue pathways, thus leading to complex biomacromolecule modification. Death from mechanical asphyxia refers to death due to acute respiratory disorder caused by mechanical violence. Because of the absence of characteristic signs in corpse, the accurate identification of mechanical asphyxia has always been the difficulty in forensic pathology. This paper reviews the biomacromolecule changes under the pulmonary hypoxia condition and discusses the possibility of application of these changes to accurate identification of death from mechanical asphyxia, aiming to provide new ideas for related research.
