Uric acid-lymphocyte ratios and myocardial damage parameters in ST elevated myocardial infarction

Abstract

AbstractBackground/Aims:Studies recently have demonstrated the association between the major cardiovascular poor outcomes and uricacid (UA), the neutrophil/lymphocyteratio (NLR), lymphocyte counts. Barely, the relation between uricacid-to-lymphocyteratio (UALR) levels and inflammatory markers in ST elevated myocardial infarction (STEMI) hasn’t been investigated yet. In our current study, we tried to investigate whether alterations UALR levels between patients unstable angina pectoris (UAP) patients and STEMI patients who underwent primary percutaneous coronary intervention (PCI). In this context, were searched that altherelations of UALR with myocardial injury markers (troponin I, creatine kinase-MB), inflammatory markers (C-reactive protein, and covariaties of blood count), patients' lipid profiles and myocardial contractility.Methods:A total of 346 STEMI and UAP patients were enrolled in this retrospectively study. T-test or Mann Witney U test was used to see the significant differences. We found independent predictive factors for UA, NLR, and UALR for STEMI and ROC analyses was performed for these parameters. Results:We showed significant differences between UA, NLR and UALR levels (P lt;0.005)between STEMI and UAP patients. We determined the optimal cut-off points as: 6.05mg/dL for UA (UAC 0.561, specifity%50, sensitivity%72); 0.179 for UALR (UAC 0.913, specifity%96,sensitivity %92) ;2.3 for NLR (UAC 0.395, specifity %82, sensitivity %88). Conclusions: For the first time in the literature, it has been demonstrated that UALR is a distinct parameter associated with troponin I levels and myocardial contractility, and is more sensitive and specific than the NLR, UA and CRP parameters routinely used in STEMI.

Keywords

• uric acid
• lymphocyte
• neutrophyl-to-lymphocyteratio
• myocardial infarction
• ürik asit
• lenfosit
• nötrofil/lenfosit oranı
• miyokard enfarktüsü
• koroner anjiyografi