Lignan Glycosides from <i>Urena lobata</i>

Abstract

Four new lignan glycosides; urenalignosides A−D (1−4), along with 12 known ones (5−16) were isolated from Urena lobata. Their structures were determined on the basis of extensive spectroscopic and spectrometric data (1D and 2D NMR; IR; CD; and HRESIMS). Compounds 2−4; 6; 7; 10; and 11 showed inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophage cells with IC50 values in the range of 25.5−98.4 μM (positive control; quercetin; IC50 = 7.2 ± 0.2 μM).

Keywords

• <i>Urena lobata</i> L.
• lignan glycosides
• urenalignosides A–D
• nitric oxide production