A new member of the fusaricidin family – structure elucidation and synthesis of fusaricidin E

Abstract

Two hitherto unknown fusaricidins were obtained from fermentation broths of three Paenibacillus strains. After structure elucidation based on tandem mass spectrometry and NMR spectroscopy, fusaricidin E was synthesized to confirm the structure and the suggested stereochemistry. The synthesis was based on a new strategy which includes an efficient access to the 15-guanidino-3-hydroxypentadecanoyl (GHPD) side chain from erucamide.

Keywords

• cyclodepsipeptides
• fusaricidins
• lipopeptides
• structure elucidation
• total synthesis