Treatment Outcomes of Pediatric Acute Myeloid Leukemia in the Yeungnam Region: A Multicenter Retrospective Study of the Study Alliance of Yeungnam Pediatric Hematology–Oncology (SAYPH)
Jae Min Lee,
Eu Jeen Yang,
Kyung Mi Park,
Young-Ho Lee,
Heewon Chueh,
Jeong Ok Hah,
Ji Kyoung Park,
Jae Young Lim,
Eun Sil Park,
Sang Kyu Park,
Heung Sik Kim,
Ye Jee Shim,
Jeong A. Park,
Eun Jin Choi,
Kun Soo Lee,
Ji Yoon Kim,
Young Tak Lim
Affiliations
Jae Min Lee
Department of Pediatrics, College of Medicine, Yeungnam University, Daegu 42415, Korea
Eu Jeen Yang
Department of Pediatrics, Pusan National University Children’s Hospital, Pusan National University, School of Medicine, Yangsan 50612, Korea
Kyung Mi Park
Department of Pediatrics, Pusan National University Children’s Hospital, Pusan National University, School of Medicine, Yangsan 50612, Korea
Young-Ho Lee
Department of Pediatrics, Hanyang University College of Medicine, Hanyang University Medical Center, Seoul 04763, Korea
Heewon Chueh
Department of Pediatrics, Dong-A University College of Medicine, Busan 49201, Korea
Jeong Ok Hah
Department of Pediatrics, Daegu Fatima Hospital, Daegu 41199, Korea
Ji Kyoung Park
Department of Pediatrics, Inje University College of Medicine, Busan Paik Hospital, Busan 47392, Korea
Jae Young Lim
Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju 52727, Korea
Eun Sil Park
Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju 52727, Korea
Sang Kyu Park
Department of Pediatrics, Ulsan University Hospital, Ulsan 44033, Korea
Heung Sik Kim
Department of Pediatrics, Keimyung University School of Medicine, Keimyung University Daegu Dongsan Hospital, Daegu 41931, Korea
Ye Jee Shim
Department of Pediatrics, Keimyung University School of Medicine, Keimyung University Dongsan Hospital, Daegu 42601, Korea
Jeong A. Park
Department of Pediatrics, Inje University Haeundae Paik Hospital, Busan 41808, Korea
Eun Jin Choi
Department of Pediatrics, Daegu Catholic University Medical Center, Daegu 42472, Korea
Kun Soo Lee
Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu 41944, Korea
Ji Yoon Kim
Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu 41944, Korea
Young Tak Lim
Department of Pediatrics, Pusan National University Children’s Hospital, Pusan National University, School of Medicine, Yangsan 50612, Korea
Acute myeloid leukemia (AML) is the second most common pediatric leukemia, with a survival rate of 70%. In this retrospective study, we evaluated the treatment outcomes of pediatric AML among 144 patients diagnosed between 2000 and 2013. After induction, 80.6% of patients achieved complete remission (CR). The 5-year overall survival (OS) and event-free survival (EFS) rates were 58.8 ± 4.2% and 49.8 ± 4.2%, respectively. Based on the response to induction therapy, the 5-year OS was 66.9 ± 5.7% in patients with CR (p p = 0.089). The EFS was 50.1 ± 7.4% in the chemotherapy group and 61.7 ± 6.9% in the HSCT group (p = 0.098). OS and EFS according to cytogenetics were insignificant. Our findings confirmed that the response to induction treatment was important for survival and HSCT had no significant survival benefits compared with those of chemotherapy. Moreover, many early induction deaths under the age of 2 years were observed.
