HLA-targeted sequencing reveals the pathogenic role of HLA-B*15:02/HLA-B*13:01 in albendazole-induced liver failure: a case report and a review of the literature

Jin-Mao Liao; Yan Zhan; Yan Zhan; Yan Zhan; Yan Zhan; Zheng Zhang; Jia-Jia Cui; Jia-Jia Cui; Jia-Jia Cui; Jia-Jia Cui; Jia-Jia Cui; Ji-Ye Yin; Ji-Ye Yin; Ji-Ye Yin; Ji-Ye Yin

doi:10.3389/fphar.2023.1288068

Frontiers in Pharmacology (Nov 2023)

HLA-targeted sequencing reveals the pathogenic role of HLA-B15:02/HLA-B13:01 in albendazole-induced liver failure: a case report and a review of the literature

Jin-Mao Liao,
Yan Zhan,
Yan Zhan,
Yan Zhan,
Yan Zhan,
Zheng Zhang,
Jia-Jia Cui,
Jia-Jia Cui,
Jia-Jia Cui,
Jia-Jia Cui,
Jia-Jia Cui,
Ji-Ye Yin,
Ji-Ye Yin,
Ji-Ye Yin,
Ji-Ye Yin

Affiliations

Jin-Mao Liao: Department of Hepotology, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
Yan Zhan: Department of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Xiangya Hospital, Central South University, Changsha, China
Yan Zhan: Institute of Clinical Pharmacology, Central South University, Changsha, China
Yan Zhan: Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Central South University, Changsha, China
Yan Zhan: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Zheng Zhang: Department of Hepotology, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China
Jia-Jia Cui: Department of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Xiangya Hospital, Central South University, Changsha, China
Jia-Jia Cui: Institute of Clinical Pharmacology, Central South University, Changsha, China
Jia-Jia Cui: Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Central South University, Changsha, China
Jia-Jia Cui: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Jia-Jia Cui: Department of Geriatric Surgery, Xiangya Hospital, Central South University, Changsha, China
Ji-Ye Yin: Department of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Xiangya Hospital, Central South University, Changsha, China
Ji-Ye Yin: Institute of Clinical Pharmacology, Central South University, Changsha, China
Ji-Ye Yin: Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Central South University, Changsha, China
Ji-Ye Yin: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

DOI: https://doi.org/10.3389/fphar.2023.1288068
Journal volume & issue: Vol. 14

Abstract

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Drug-induced liver injury (DILI) is one of the serious adverse drug reactions (ADRs), which belongs to immune-mediated adverse drug reactions (IM-ADRs). As an essential health drug, albendazole has rarely been reported to cause serious liver damage. A young man in his 30 s developed severe jaundice, abnormal transaminases, and poor blood coagulation mechanism after taking albendazole, and eventually developed into severe liver failure. The patient was found heterozygous of HLA-B*15:02 and HLA-B*13:01 through HLA-targeted sequencing, which may have a pathogenic role in the disease. This case report summarizes his presentation, treatment, and prognosis. A useful summary of the diagnosis and associated genetic variant information is provided.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

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