Nature Communications (Sep 2018)

Persistent repair intermediates induce senescence

  • F. M. Feringa,
  • J. A. Raaijmakers,
  • M. A. Hadders,
  • C. Vaarting,
  • L. Macurek,
  • L. Heitink,
  • L. Krenning,
  • R. H. Medema

DOI
https://doi.org/10.1038/s41467-018-06308-9
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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Cells with damaged DNA can permanently exit the cell cycle during the G2 phase or recover spontaneously entering mitosis. Here the authors reveal that the decision to exit from the cell cycle in G2 is dependent on the presence of repair intermediates associated with homologous recombination.