Green design, synthesis of novel 2-methoxy-3-aryl-1,8-naphthyridines and their biological and molecular docking study

Abstract

An efficient and rapid synthesis of novel substituted 2-methoxy-3-aryl-1,8-naphthyridines 5(a-j) by the reaction of 2-chloro-3-aryl-1,8-naphthyridines with sodium methoxide in ethanol under controlled microwave irradiation as well as conventional methods are described. The products are obtained in very good yields and in a state of high purity. The elemental analysis, spectral data and mass spectral data were used to characterize all of the novel analogs. The newly synthesized molecules were screened for their antimicrobial activity. In vitro study reveals the antimicrobial activity of compounds 5e and 5 g has shown excellent activity with tested microbes. Furthermore, the results of molecular docking confirmed the experimental findings.

Keywords

• 1,8-Naphthyridines
• Sodium methoxide
• Ethanol
• Microwave
• Antimicrobial activity
• Molecular docking studies