Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics

Shuai Gao; Guoguang Wei; Sihang Zhang; Binbin Zheng; Jiaojiao Xu; Gaoxian Chen; Mingwang Li; Shaoli Song; Wei Fu; Zeyu Xiao; Wei Lu

doi:10.1038/s41467-019-10056-9

Nature Communications (May 2019)

Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics

Shuai Gao,
Guoguang Wei,
Sihang Zhang,
Binbin Zheng,
Jiaojiao Xu,
Gaoxian Chen,
Mingwang Li,
Shaoli Song,
Wei Fu,
Zeyu Xiao,
Wei Lu

Affiliations

Shuai Gao: Key Laboratory of Smart Drug Delivery, Ministry of Education, & State Key Laboratory of Molecular Engineering of Polymers, School of Pharmacy & Minhang Hospital, Fudan University
Guoguang Wei: Key Laboratory of Smart Drug Delivery, Ministry of Education, & State Key Laboratory of Molecular Engineering of Polymers, School of Pharmacy & Minhang Hospital, Fudan University
Sihang Zhang: Key Laboratory of Smart Drug Delivery, Ministry of Education, & State Key Laboratory of Molecular Engineering of Polymers, School of Pharmacy & Minhang Hospital, Fudan University
Binbin Zheng: Key Laboratory of Smart Drug Delivery, Ministry of Education, & State Key Laboratory of Molecular Engineering of Polymers, School of Pharmacy & Minhang Hospital, Fudan University
Jiaojiao Xu: Key Laboratory of Smart Drug Delivery, Ministry of Education, & State Key Laboratory of Molecular Engineering of Polymers, School of Pharmacy & Minhang Hospital, Fudan University
Gaoxian Chen: Institute of Molecular Medicine, Clinical and Fundamental Research Center, Renji Hospital, & Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine
Mingwang Li: Institute of Molecular Medicine, Clinical and Fundamental Research Center, Renji Hospital, & Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine
Shaoli Song: Department of Nuclear Medicine, Shanghai Cancer Center, Fudan University
Wei Fu: Key Laboratory of Smart Drug Delivery, Ministry of Education, & State Key Laboratory of Molecular Engineering of Polymers, School of Pharmacy & Minhang Hospital, Fudan University
Zeyu Xiao: Institute of Molecular Medicine, Clinical and Fundamental Research Center, Renji Hospital, & Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine
Wei Lu: Key Laboratory of Smart Drug Delivery, Ministry of Education, & State Key Laboratory of Molecular Engineering of Polymers, School of Pharmacy & Minhang Hospital, Fudan University

DOI: https://doi.org/10.1038/s41467-019-10056-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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There is a balance between the fluorescence and photothermal properties of fluorescent molecules. Here, the authors report on an NIR-II fluorophore which binds with human serum albumin changing the equilibrium, increasing the photothermal efficiency, and demonstrate application of this for tumour ablation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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