Communications Biology (Jul 2021)
Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action
- Rachel L. Palte,
- Veronica Juan,
- Yacob Gomez-Llorente,
- Marc Andre Bailly,
- Kalyan Chakravarthy,
- Xun Chen,
- Daniel Cipriano,
- Laurence Fayadat-Dilman,
- Symon Gathiaka,
- Heiko Greb,
- Brian Hall,
- Mas Handa,
- Mark Hsieh,
- Esther Kofman,
- Heping Lin,
- J. Richard Miller,
- Nhung Nguyen,
- Jennifer O’Neil,
- Hussam Shaheen,
- Eric Sterner,
- Corey Strickland,
- Angie Sun,
- Shane Taremi,
- Giovanna Scapin
Affiliations
- Rachel L. Palte
- Department of Discovery Chemistry, Merck & Co., Inc.
- Veronica Juan
- Department of Discovery Biologics, Merck & Co., Inc.
- Yacob Gomez-Llorente
- Department of Discovery Chemistry, Merck & Co., Inc.
- Marc Andre Bailly
- Department of Discovery Biologics, Merck & Co., Inc.
- Kalyan Chakravarthy
- Department of Discovery Biology, Merck & Co., Inc.
- Xun Chen
- Department of Discovery Chemistry, Merck & Co., Inc.
- Daniel Cipriano
- Department of Discovery Biologics, Merck & Co., Inc.
- Laurence Fayadat-Dilman
- Department of Discovery Biologics, Merck & Co., Inc.
- Symon Gathiaka
- Department of Discovery Chemistry, Merck & Co., Inc.
- Heiko Greb
- Department of Discovery Biologics, Merck & Co., Inc.
- Brian Hall
- Department of Discovery Biologics, Merck & Co., Inc.
- Mas Handa
- Department of Discovery Biologics, Merck & Co., Inc.
- Mark Hsieh
- Department of Discovery Biologics, Merck & Co., Inc.
- Esther Kofman
- Department of Discovery Biologics, Merck & Co., Inc.
- Heping Lin
- Department of Discovery Biologics, Merck & Co., Inc.
- J. Richard Miller
- Department of Discovery Biology, Merck & Co., Inc.
- Nhung Nguyen
- Department of Discovery Biologics, Merck & Co., Inc.
- Jennifer O’Neil
- Department of Discovery Oncology, Merck & Co., Inc.
- Hussam Shaheen
- Department of Discovery Biologics, Merck & Co., Inc.
- Eric Sterner
- Department of Discovery Biologics, Merck & Co., Inc.
- Corey Strickland
- Department of Discovery Chemistry, Merck & Co., Inc.
- Angie Sun
- Department of Discovery Biologics, Merck & Co., Inc.
- Shane Taremi
- Department of Discovery Biologics, Merck & Co., Inc.
- Giovanna Scapin
- Department of Discovery Chemistry, Merck & Co., Inc.
- DOI
- https://doi.org/10.1038/s42003-021-02444-z
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 13
Abstract
Palte et al provide cryo-EM structures of five potent and inhibitory monoclonal antibodies bound to human Arginase 1, a T-cell modulating metalloenzyme and a cancer drug target. They provide structural insights that will aid in the evaluation of these antibodies as therapeutic inhibitors of arginasemediated T-cell suppression.
