Marine Drugs (Sep 2019)

Antimicrobial Lavandulylated Flavonoids from a Sponge-Derived <i>Streptomyces</i> sp. G248 in East Vietnam Sea

  • Duc Danh Cao,
  • Thi Thanh Van Trinh,
  • Huong Doan Thi Mai,
  • Van Nam Vu,
  • Hong Minh Le,
  • Quyen Vu Thi,
  • Mai Anh Nguyen,
  • Thu Trang Duong,
  • Dang Thach Tran,
  • Van Minh Chau,
  • Rui Ma,
  • Gauri Shetye,
  • Sanghyun Cho,
  • Brian T. Murphy,
  • Van Cuong Pham

DOI
https://doi.org/10.3390/md17090529
Journal volume & issue
Vol. 17, no. 9
p. 529

Abstract

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Three new lavandulylated flavonoids, (2S,2″S)-6-lavandulyl-7,4′-dimethoxy-5,2′-dihydroxylflavanone (1), (2S,2″S)-6-lavandulyl-5,7,2′,4′-tetrahydroxylflavanone (2), and (2″S)-5′-lavandulyl-2′-methoxy-2,4,4′,6′-tetrahydroxylchalcone (3), along with seven known compounds 4−10 were isolated from culture broth of Streptomyces sp. G248. Their structures were established by spectroscopic data analysis, including 1D and 2D nuclear magnetic resonance (NMR), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). The absolute configurations of 1−3 were resolved by comparison of their experimental and calculated electronic circular dichroism spectra. Compounds 1−3 exhibited remarkable antimicrobial activity. Whereas, two known compounds 4 and 5 exhibited inhibitory activity against Mycobacterium tuberculosis H37Rv with minimum inhibitory concentration (MIC) values of 6.0 µg/mL and 11.1 µg/mL, respectively.

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