A Computational Assay that Explores the Hemagglutinin/Neuraminidase Functional Balance Reveals the Neuraminidase Secondary Site as a Novel Anti-Influenza Target

• Rommie E. Amaro,
• Pek U Ieong,
• Gary Huber,
• Abigail Dommer,
• Alasdair C. Steven,
• Robin M. Bush,
• Jacob D. Durrant,
• Lane W. Votapka

Affiliations

Rommie E. Amaro

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States

Pek U Ieong

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States

Gary Huber

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States

Abigail Dommer

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States

Alasdair C. Steven

Structural Biology Laboratory, National Institutes of Health, Bethesda, Maryland, United States

Robin M. Bush

Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, California, United States

Jacob D. Durrant

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States

Lane W. Votapka

Department of Chemistry, Point Loma Nazarene University, San Diego, California, United States