Intestinal microbiota and allergic diseases

Abstract

The increase in allergic diseases over the past several decades is correlated with changes in the composition and diversity of the intestinal microbiota, which plays a significant role in the development of the immune system of the child. There are presented data on the role of the intestinal microbiota, the organization and the factors influencing the development of immunity. It is shown that microbial colonization in the early stages of life is influenced by various factors. Early postnatal life is a key time for the development of the immune system and the colonization of the host microbiota. Microbial deprivation is the cause of allergic diseases. The ability of intestine microbiota to influence immune response resulted in novel approaches in therapy that use these differences in microbiota for therapy and prevention in allergy patients. And therefore on the basis of «hygiene hypothesis» of allergy emergence, a consideration is expressed that early manipulation with intestinal microbial communities may offer a new strategy of allergic sensibilization prevention.

Keywords

• intestinal microbiota
• allergic diseases
• atopy
• immunity