DEPENDENCE OF OUTCOMES OF HYPERTROPHIC SCARS LASER TREATMENT ON THE INITIAL REACTIVITY

Abstract

The purpose of the study was to identify the relationship between the initial state of the organism and the result of the treatment of hypertrophic scars. 38 women of 16-35years of age were examined on the 5-7th days of the menstrual cycle, 16 of them had normotrophic scars and 22 - hypertrophic scars. The quality of scars, lipid profile, the concentration of thyrotropin, free fraction of thyroxine, growth hormone (GH), luteinizing and follicle stimulating hormone (FSH), cortisol, prolactin, estradiol, testosterone, progesterone, the concentration of TNF-a, lL-4, lL-6, lL-10, and the level of autoantibodies to DNA, lFN-a, lFN-y, b2-glycoprotein, Fc-fragments, collagen-2 were determined. Further on the laser treatment was performed: the scar surface was treated by multiple perforations under local anesthesia. Treatment outcome was assessed in 3 months by the clinical characteristics of the scar. lt was found that in 10 women hypertrophic scars reformed in normotrophic scars after the treatment, and 12 women still had hypertrophic scars. Patients with a positive result of treatment had a low concentration of GH (0.5 ± 0.1) and high concentrations of progesterone (6.0 ± 0.4) and FSH (6.7 ± 0.5 in the follicular phase of the cycle). The negative result of the treatment obtained in patients with significant shifts reactivity indicators: high atherogenic index (2.6 ± 0.2) and the level of GH (2.1 ± 0.5), low levels of cortisol (346.8 ± 39), testosterone (1.5 ± 0.2), lL-10 (3.89 ± 1.6) and antibodies to lFN-y (0.206 ± 0.05), lFN-a (0.385 ± 0.02), Fc-fragments (0.317± 0.04).

Keywords

• treatment of hypertrophic scars
• reactivity
• pathogenesis of hypertrophic scars