Zebrafish model and intracranial hemorrhage: a review from genetic to molecular mechanism perspectives

Abstract

Intracranial hemorrhage (ICH) is the most common acute progressive cerebrovascular disease in aging population. Although the pathogenesis of ICH remains unclear, a great many mechanism researches have shown that the blood⁃brain barrier (BBB) regulated by different genetic factors may play an important role. As classic animal model for hemorrhagic cerebrovascular disease, the ICH zebrafish model plays a key role in the studies for mechanisms of genetic factors. In this article, we comprehensively reviews the characteristics and advantages of ICH zebrafish model, and also makes an updated introductions on genetic and molecular aspects of BBB structures and functions based on common transgenic ICH zebrafish model. Therefore, we explain the relationship between ICH and related gene expression, in order to deepen current understanding on ICH pathogenesis and help to make relevant strategy for prevention and treatment. doi：10.3969/j.issn.1672⁃6731.2021.02.005

Keywords

• cerebral hemorrhage
• blood⁃brain barrier
• zebrafish
• genetics
• genes
• review