Features of carbohydrate metabolism disorders in acute pancreatitis

Abstract

Introduction. Endocrine insufficiency of the pancreas manifests, as a rule, in the form of carbohydrate metabolism disorders.Methods and materials. The levels of insulin concentration were analyzed in 21 patients with various forms of acute pancreatitis with a degree of clinical severity on the APACHE II scale from 10 to 14 (12±2) and the levels of glucagon concentration in 16 patients with a degree of clinical severity on the APACHE II scale from 8 to 10 (9±1) on the 1st, 3rd and 7th day since the onset of disease, the dynamics of blood glycemia was observed in all patients.Results. As a result, despite the relatively normal blood glucose level in all observations compared with the control group, there was a decrease in insulin by more than 2 times, a decrease in glucagon by 1.5 times, the level of which increased by the outcome of the disease. In the presence of normoglycemia in all studied cases.Conclusions. The obtained data indicates that insufficiency of insulin and glucagon exists in all forms of AP. Relative normoglycemia is caused by absolute insulin insufficiency against the background of interstitial edema of the pancreas in AP. Correction of endocrine disorders in AP is a promising direction in the treatment of patients with various forms of AP.

Keywords

• pancreas
• acute pancreatitis
• diabetes mellitus
• insulin
• glucagon