Nature Communications (Jul 2022)

Cohesin couples transcriptional bursting probabilities of inducible enhancers and promoters

  • Irene Robles-Rebollo,
  • Sergi Cuartero,
  • Adria Canellas-Socias,
  • Sarah Wells,
  • Mohammad M. Karimi,
  • Elisabetta Mereu,
  • Alexandra G. Chivu,
  • Holger Heyn,
  • Chad Whilding,
  • Dirk Dormann,
  • Samuel Marguerat,
  • Inmaculada Rioja,
  • Rab K. Prinjha,
  • Michael P. H. Stumpf,
  • Amanda G. Fisher,
  • Matthias Merkenschlager

DOI
https://doi.org/10.1038/s41467-022-31192-9
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 16

Abstract

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Here the authors show inducible genes and enhancers are regulated mainly by transcriptional burst frequency and that this is coordinated in single cells and individual alleles. Cohesin, which is important for inducible gene expression, is largely dispensable for regulating enhancer burst frequencies; however, it is required for coupling burst frequencies of inducible enhancers and promoters.