Computational modelling in disorders of consciousness: Closing the gap towards personalised models for restoring consciousness
Andrea I. Luppi,
Joana Cabral,
Rodrigo Cofre,
Pedro A.M. Mediano,
Fernando E. Rosas,
Abid Y. Qureshi,
Amy Kuceyeski,
Enzo Tagliazucchi,
Federico Raimondo,
Gustavo Deco,
James M. Shine,
Morten L. Kringelbach,
Patricio Orio,
ShiNung Ching,
Yonatan Sanz Perl,
Michael N. Diringer,
Robert D. Stevens,
Jacobo Diego Sitt
Affiliations
Andrea I. Luppi
Division of Anaesthesia and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; Corresponding author at: Division of Anaesthesia and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Joana Cabral
Life and Health Sciences Research Institute, University of Minho, Portugal
Rodrigo Cofre
CIMFAV-Ingemat, Facultad de Ingeniería, Universidad de Valparaíso, Valparaíso, Chile; Centre National de la Recherche Scientifique (CNRS), Institute of Neuroscience (NeuroPSI), Paris-Saclay University, Gif-sur-Yvette, France
Pedro A.M. Mediano
Department of Computing, Imperial College London, London, UK; Department of Psychology, University of Cambridge, Cambridge, UK
Fernando E. Rosas
Department of Informatics, University of Sussex, Brighton, UK; Centre for Psychedelic Research, Department of Brain Sciences, Imperial College London, London, UK; Centre for Complexity Science, Imperial College London, London, UK; Centre for Eudaimonia and Human Flourishing, Linacre College, University of Oxford, Oxford, UK
Abid Y. Qureshi
University of Kansas Medical Center, Kansas City, MO, USA
Amy Kuceyeski
Department of Radiology, Weill Cornell Medicine, New York, USA
Enzo Tagliazucchi
Departamento de Física (UBA) e Instituto de Fisica de Buenos Aires (CONICET), Buenos Aires, Argentina; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile
Federico Raimondo
Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich, Germany; Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Gustavo Deco
Center for Brain and Cognition, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain; Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain; Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia
James M. Shine
Brain and Mind Center, The University of Sydney, Sydney, Australia
Morten L. Kringelbach
Centre for Eudaimonia and Human Flourishing, Linacre College, University of Oxford, Oxford, UK; Department of Psychiatry, University of Oxford, Oxford, UK; Center for Music in the Brain, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Patricio Orio
Centro Interdisciplinario de Neurociencia de Valparaíso and Instituto de Neurociencia, Universidad de Valparaíso, Valparaíso, Chile
ShiNung Ching
Electrical and Systems Engineering, Washington University in St. Louis, St. Louis, MO, USA
Yonatan Sanz Perl
Center for Brain and Cognition, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain; Institut du Cerveau et de la Moelle épinière - Paris Brain Institute, ICM, Paris, France; National Scientific and Technical Research Council (CONICET), Godoy Cruz, CABA 2290, Argentina
Michael N. Diringer
Department of Neurology and Neurosurgery, Washington University in St. Louis, St. Louis, MO, USA
Robert D. Stevens
Departments of Anesthesiology and Critical Care Medicine, Neurology, and Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA
Jacobo Diego Sitt
Institut du Cerveau et de la Moelle épinière - Paris Brain Institute, ICM, Paris, France; Sorbonne Université, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, Paris, France; Corresponding author at: Institut du Cerveau et de la Moelle épinière - Paris Brain Institute, ICM, Paris, France.
Disorders of consciousness are complex conditions characterised by persistent loss of responsiveness due to brain injury. They present diagnostic challenges and limited options for treatment, and highlight the urgent need for a more thorough understanding of how human consciousness arises from coordinated neural activity. The increasing availability of multimodal neuroimaging data has given rise to a wide range of clinically- and scientifically-motivated modelling efforts, seeking to improve data-driven stratification of patients, to identify causal mechanisms for patient pathophysiology and loss of consciousness more broadly, and to develop simulations as a means of testing in silico potential treatment avenues to restore consciousness. As a dedicated Working Group of clinicians and neuroscientists of the international Curing Coma Campaign, here we provide our framework and vision to understand the diverse statistical and generative computational modelling approaches that are being employed in this fast-growing field. We identify the gaps that exist between the current state-of-the-art in statistical and biophysical computational modelling in human neuroscience, and the aspirational goal of a mature field of modelling disorders of consciousness; which might drive improved treatments and outcomes in the clinic. Finally, we make several recommendations for how the field as a whole can work together to address these challenges.
