Gut microbiota-metabolite interactions meditate the effect of dietary patterns on precocious puberty

Ying Wang; Chuandi Jin; Hongying Li; Xiangrong Liang; Changying Zhao; Nan Wu; Min Yue; Lu Zhao; Han Yu; Qian Wang; Yongsheng Ge; Meiling Huo; Xin Lv; Lehai Zhang; Guoping Zhao; Zhongtao Gai

iScience (Jun 2024)

Gut microbiota-metabolite interactions meditate the effect of dietary patterns on precocious puberty

Ying Wang,
Chuandi Jin,
Hongying Li,
Xiangrong Liang,
Changying Zhao,
Nan Wu,
Min Yue,
Lu Zhao,
Han Yu,
Qian Wang,
Yongsheng Ge,
Meiling Huo,
Xin Lv,
Lehai Zhang,
Guoping Zhao,
Zhongtao Gai

Affiliations

Ying Wang: Children’s Hospital Affiliated to Shandong University, Shandong University, Jinan 250022, China; Jinan Children’s Hospital, Jinan 250022, China
Chuandi Jin: Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China; Microbiome-X, National Institute of Health Data Science of China, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
Hongying Li: Children’s Hospital Affiliated to Shandong University, Shandong University, Jinan 250022, China; Jinan Children’s Hospital, Jinan 250022, China
Xiangrong Liang: Children’s Hospital Affiliated to Shandong University, Shandong University, Jinan 250022, China; Jinan Children’s Hospital, Jinan 250022, China
Changying Zhao: Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China; Microbiome-X, National Institute of Health Data Science of China, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
Nan Wu: Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China; Microbiome-X, National Institute of Health Data Science of China, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
Min Yue: Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China; Microbiome-X, National Institute of Health Data Science of China, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
Lu Zhao: Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China; Central Laboratory, Weifang People’s Hospital/The First Affiliated Hospital of Shandong Second Medical university, Weifang 261000, China; Shandong Laibo Biotechnology Co., Ltd., Jinan 250101, China
Han Yu: Children’s Hospital Affiliated to Shandong University, Shandong University, Jinan 250022, China; Jinan Children’s Hospital, Jinan 250022, China
Qian Wang: Children’s Hospital Affiliated to Shandong University, Shandong University, Jinan 250022, China; Jinan Children’s Hospital, Jinan 250022, China
Yongsheng Ge: Children’s Hospital Affiliated to Shandong University, Shandong University, Jinan 250022, China; Jinan Children’s Hospital, Jinan 250022, China
Meiling Huo: Children’s Hospital Affiliated to Shandong University, Shandong University, Jinan 250022, China; Jinan Children’s Hospital, Jinan 250022, China
Xin Lv: Children’s Hospital Affiliated to Shandong University, Shandong University, Jinan 250022, China; Jinan Children’s Hospital, Jinan 250022, China
Lehai Zhang: Children’s Hospital Affiliated to Shandong University, Shandong University, Jinan 250022, China; Jinan Children’s Hospital, Jinan 250022, China
Guoping Zhao: Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China; Microbiome-X, National Institute of Health Data Science of China, Cheeloo College of Medicine, Shandong University, Jinan 250012, China; CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China; Corresponding author
Zhongtao Gai: Children’s Hospital Affiliated to Shandong University, Shandong University, Jinan 250022, China; Jinan Children’s Hospital, Jinan 250022, China; Corresponding author

Journal volume & issue: Vol. 27, no. 6
p. 109887

Abstract

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Summary: Precocious puberty, a pediatric endocrine disorder classified as central precocious puberty (CPP) or peripheral precocious puberty (PPP), is influenced by diet, gut microbiota, and metabolites, but the specific mechanisms remain unclear. Our study found that increased alpha-diversity and abundance of short-chain fatty acid–producing bacteria led to elevated levels of luteinizing hormone and follicle-stimulating hormone, contributing to precocious puberty. The integration of specific microbiota and metabolites has potential diagnostic value for precocious puberty. The Prevotella genus-controlled interaction factor, influenced by complex carbohydrate consumption, mediated a reduction in estradiol levels. Interactions between obesity-related bacteria and metabolites mediated the beneficial effect of seafood in reducing luteinizing hormone levels, reducing the risk of obesity-induced precocious puberty, and preventing progression from PPP to CPP. This study provides valuable insights into the complex interplay between diet, gut microbiota and metabolites in the onset, development and clinical classification of precocious puberty and warrants further investigation.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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