Gut microbiota-metabolite interactions meditate the effect of dietary patterns on precocious puberty
Ying Wang,
Chuandi Jin,
Hongying Li,
Xiangrong Liang,
Changying Zhao,
Nan Wu,
Min Yue,
Lu Zhao,
Han Yu,
Qian Wang,
Yongsheng Ge,
Meiling Huo,
Xin Lv,
Lehai Zhang,
Guoping Zhao,
Zhongtao Gai
Affiliations
Ying Wang
Children’s Hospital Affiliated to Shandong University, Shandong University, Jinan 250022, China; Jinan Children’s Hospital, Jinan 250022, China
Chuandi Jin
Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China; Microbiome-X, National Institute of Health Data Science of China, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
Hongying Li
Children’s Hospital Affiliated to Shandong University, Shandong University, Jinan 250022, China; Jinan Children’s Hospital, Jinan 250022, China
Xiangrong Liang
Children’s Hospital Affiliated to Shandong University, Shandong University, Jinan 250022, China; Jinan Children’s Hospital, Jinan 250022, China
Changying Zhao
Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China; Microbiome-X, National Institute of Health Data Science of China, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
Nan Wu
Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China; Microbiome-X, National Institute of Health Data Science of China, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
Min Yue
Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China; Microbiome-X, National Institute of Health Data Science of China, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
Lu Zhao
Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China; Central Laboratory, Weifang People’s Hospital/The First Affiliated Hospital of Shandong Second Medical university, Weifang 261000, China; Shandong Laibo Biotechnology Co., Ltd., Jinan 250101, China
Han Yu
Children’s Hospital Affiliated to Shandong University, Shandong University, Jinan 250022, China; Jinan Children’s Hospital, Jinan 250022, China
Qian Wang
Children’s Hospital Affiliated to Shandong University, Shandong University, Jinan 250022, China; Jinan Children’s Hospital, Jinan 250022, China
Yongsheng Ge
Children’s Hospital Affiliated to Shandong University, Shandong University, Jinan 250022, China; Jinan Children’s Hospital, Jinan 250022, China
Meiling Huo
Children’s Hospital Affiliated to Shandong University, Shandong University, Jinan 250022, China; Jinan Children’s Hospital, Jinan 250022, China
Xin Lv
Children’s Hospital Affiliated to Shandong University, Shandong University, Jinan 250022, China; Jinan Children’s Hospital, Jinan 250022, China
Lehai Zhang
Children’s Hospital Affiliated to Shandong University, Shandong University, Jinan 250022, China; Jinan Children’s Hospital, Jinan 250022, China
Guoping Zhao
Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China; Microbiome-X, National Institute of Health Data Science of China, Cheeloo College of Medicine, Shandong University, Jinan 250012, China; CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China; Corresponding author
Summary: Precocious puberty, a pediatric endocrine disorder classified as central precocious puberty (CPP) or peripheral precocious puberty (PPP), is influenced by diet, gut microbiota, and metabolites, but the specific mechanisms remain unclear. Our study found that increased alpha-diversity and abundance of short-chain fatty acid–producing bacteria led to elevated levels of luteinizing hormone and follicle-stimulating hormone, contributing to precocious puberty. The integration of specific microbiota and metabolites has potential diagnostic value for precocious puberty. The Prevotella genus-controlled interaction factor, influenced by complex carbohydrate consumption, mediated a reduction in estradiol levels. Interactions between obesity-related bacteria and metabolites mediated the beneficial effect of seafood in reducing luteinizing hormone levels, reducing the risk of obesity-induced precocious puberty, and preventing progression from PPP to CPP. This study provides valuable insights into the complex interplay between diet, gut microbiota and metabolites in the onset, development and clinical classification of precocious puberty and warrants further investigation.
