Potential of diterpene compounds as antivirals, a review
Andika Pramudya Wardana,
Nanik Siti Aminah,
Mila Rosyda,
Muhammad Ikhlas Abdjan,
Alfinda Novi Kristanti,
Khun Nay Win Tun,
Muhammad Iqbal Choudhary,
Yoshiaki Takaya
Affiliations
Andika Pramudya Wardana
Ph.D. Student of Mathematics and Natural Sciences, Faculty of Science and Technology, Universitas Airlangga, Komplek Kampus C UNAIR, Jl. Mulyorejo, 60115, Surabaya, Indonesia; Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Komplek Kampus C UNAIR, Jl. Mulyorejo, 60115, Surabaya, Indonesia
Nanik Siti Aminah
Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Komplek Kampus C UNAIR, Jl. Mulyorejo, 60115, Surabaya, Indonesia; Biotechnology of Tropical Medicinal Plants Research Group, Universitas Airlangga, Indonesia; Corresponding author.
Mila Rosyda
Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Komplek Kampus C UNAIR, Jl. Mulyorejo, 60115, Surabaya, Indonesia
Muhammad Ikhlas Abdjan
Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Komplek Kampus C UNAIR, Jl. Mulyorejo, 60115, Surabaya, Indonesia
Alfinda Novi Kristanti
Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Komplek Kampus C UNAIR, Jl. Mulyorejo, 60115, Surabaya, Indonesia; Biotechnology of Tropical Medicinal Plants Research Group, Universitas Airlangga, Indonesia
Khun Nay Win Tun
Department of Chemistry, Pathein University, Pathein, Myanmar
Muhammad Iqbal Choudhary
H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan; Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Komplek Kampus C UNAIR, Jl. Mulyorejo, Surabaya, Indonesia
Yoshiaki Takaya
Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku, Nagoya, 468-8503, Japan; Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Komplek Kampus C UNAIR, Jl. Mulyorejo, Surabaya, Indonesia
Viruses cause widely transmitted diseases resulting in pandemic conditions. Currently, the world is being hit by the Covid-19 pandemic caused by the SAR-CoV-2 infection. Countries in the world are competing to develop antivirals to overcome this problem. Diterpene compounds derived from natural ingredients (plants, corals, algae, fungi, sponges) and synthesized products have potential as antivirals. This article summarizes the different types of diterpenes such as daphnane, tiglilane, kaurane, abietane, pimarane, labdane, dollabelane, jatrophane, dolastane, prenylated guaiane, tonantzitlolone, casbane, have antivirals activity such as targeting HIV, Coxsackie virus, herpes virus, hepatitis virus, influenza virus, Chikungunya virus, Zika virus, dengue virus, and SARS-CoV. Some compounds such as andrographolide and its derivatives show promising activity in inhibiting the influenza virus. Additionally, compounds such as pineolidic acid, forskolin, sugiol, and many other diterpene compounds showed anti-SAR-CoV activity. The diterpene compound class's high antivirals potential does not rule out the possibility that these compounds can also act as anti-SAR-CoV-2 drugs in the future.
