A comparison of the acute phase proteins in chronic aortic occlusion versus diffuse aortoiliac occlusive disease

Abstract

Background The purpose of the present study is to evaluate if there is a specific relationship of the acute-phase proteins between patients with the chronic aortic occlusion (COA) and patients with diffuse aortoiliac occlusive disease (AIOD), and to investigate if there is a correlation between the acute phase proteins and the extent of disease. Methods Sixty patients with the aortoiliac occlusive disease were divided in two groups. First group consisted of thirty patients with the angiographic signs of diffuse aortoiliac occlusive disease, Leriche type III (AIOD group). Second (COA) group consisted of 30 patients characterized by either bifurcated aortic occlusion or juxtarenal aortic occlusion. Those two groups were compared according to symptomatology, ankle-brachial index (ABI) values, traditional risk factors and some acute phase proteins (high-sensitivity C-reactive protein - hs-CRP; homocysteine) taken at inclusion. Results The median serum hs-CRP was 4.85 mg/L and 15.7 mg/L in AIOD group and COA group, respectively. The difference was statistically significant (p=0.016). The mean plasma homocysteine was 21.44±11.25 mmol/L and 14.76±7.85 mmol/L in the AIOD group and COA group, respectively. Mean plasma homocysteine was significantly higher in patients with AIOD (p=0.005). Conclusions Our data demonstrate significant difference in hs-CRP and homocysteine concentrations among two variants of aortoiliac occlusive disease. In this particular pathology as COA, high hs-CRP concentration does not associate, at least with the angiographic extent of disease.

Keywords

• chronic aortic occlusion
• acute phase proteins