Combined Effects of Ambient PM<sub>2.5</sub> and Cold Exposure on the Development of Metabolic Disorder
Zhixiu Liu,
Jia Zhang,
Dongxia Fan,
Ge Wang,
Biao Wu,
Lei Lei,
Lina Wang,
Jinzhuo Zhao,
Jianmin Chen
Affiliations
Zhixiu Liu
Department of Environmental Health, School of Public Health and the Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China
Jia Zhang
Department of Environmental Health, School of Public Health and the Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China
Dongxia Fan
Department of Environmental Health, School of Public Health and the Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China
Ge Wang
Department of Environmental Health, School of Public Health and the Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China
Biao Wu
Department of Environmental Health, School of Public Health and the Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China
Lei Lei
Department of Environmental Health, School of Public Health and the Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China
Lina Wang
IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai 200433, China
Jinzhuo Zhao
Department of Environmental Health, School of Public Health and the Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China
Jianmin Chen
IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai 200433, China
The coexistence of temperature changes and air pollution poses a severe global environmental issue, exacerbating health burdens. The aim of this study was to clarify the combined effects of ambient PM2.5 and cold exposure on the development of metabolic disorders. Male C57BL/6 mice were randomly divided into four groups: TN-FA, TN-PM, TC-FA and TC-PM. The mice were then exposed to concentrated PM2.5 or filtered air (FA) under normal (22 °C) or cold (4 °C) environment conditions for 4 weeks. Metabolic-disorder-related indicators, blood pressure, serous lipids, fasting blood glucose and insulin, energy metabolism, mitochondria and protein expression in tissues were detected for comprehensively assessing metabolic disorder. The results showed that, compared to being exposed to PM2.5 only, when mice were exposed to both PM2.5 and the cold (non-optimal), they exhibited more significant metabolic disorders regarding glucose tolerance (p p p 2.5-induced metabolic disorder. The interaction between temperature changes and air pollution implied that implementing the necessary environment-related policies is a critical and complex challenge.
