The selection of a hydrophobic 7-phenylbutyl-7-deazaadenine-modified DNA aptamer with high binding affinity for the Heat Shock Protein 70

Abstract

DNA aptamers can be selected against a wide range of therapeutic targets, however, the success rate of selective binding remains low due to the highly hydrophilic nature of the DNA backbone. Here, the authors design a hydrophobic 7-phenylbutyl-7-deazaadenine-modified DNA aptamer showing high binding affinity for the heat shock protein 70.