The Synthesis of Dicationic Extended Bis-Benzimidazoles

Abstract

The synthesis of extended dicationic bis-benzimidazoles starting from trans-1,2-bis(4-cyanophenyl)ethene and trans-1,2-bis(4-cyanophenyl)cyclopropane is reported. The target diamidines show significant in vitro activity against B. subtilis.

Keywords

• DIBAL reduction
• benzimidazoles
• amidines
• Bacillus subtilis.