Prevalence and factors associated with hepatitis B in a cohort of HIV-infected children in the Pediatric Department at Donka National Hospital, Guinea

Abstract

INTRODUCTION: Children pay a heavy price for infection with the hepatitis B virus (HBV). The objective of this work was to determine the prevalence of Hepatitis B and describe the associated factors in children at the Pediatric Department of Donka Hospital. Methods: this was a cross-sectional study of a cohort of children in the Pediatric Department of Donka Hospital. HBsAg was performed by using an immunochromatographic method. The analysis of the data was done with software R. The proportions were compared using the Chi-square test or the Fisher test at the significance level of 5%. A logistic regression model was used to explain the prevalence of hepatitis B. Results: one hundred and forty-nine children were recruited between February and July 2017. HBsAg was present in 12 children, ie 8.16% (95% CI: 4.29-13.82). The average age was 93.32 months (IQR: 6-180). Male children were the most affected (n = 11, P =0.05), with a sex ratio of 1.01. The majority (51.35%) were on AZT + 3TC + NVP pediatric form and 25% were on AZT + 3TC + NVP adult form and 23.65% on TDF + FTC + EFV. In univariate analysis, ALT, HBsAg positivity, and maternal HBV vaccination status were associated with the prevalence of HBsAg (P =0.05). Conclusion: the prevalence of co-infection in children and adults is almost identical in our context. Hence the importance of strengthening preventive measures at all levels, especially the vaccination of children and mothers.

Keywords

• hepatitis b
• hiv
• prevalence
• paediatrics
• donka national hospital
• guinea