Communications Biology (Jun 2021)

Novel lamprey antibody recognizes terminal sulfated galactose epitopes on mammalian glycoproteins

  • Tanya R. McKitrick,
  • Steffen M. Bernard,
  • Alexander J. Noll,
  • Bernard C. Collins,
  • Christoffer K. Goth,
  • Alyssa M. McQuillan,
  • Jamie Heimburg-Molinaro,
  • Brantley R. Herrin,
  • Ian A. Wilson,
  • Max D. Cooper,
  • Richard D. Cummings

DOI
https://doi.org/10.1038/s42003-021-02199-7
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 14

Abstract

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McKitrick et al engineer and characterize a novel lamprey antibody that recognizes terminal sulfated galactose epitopes on mammalian glycoproteins. This provides a new tool for the exploration of glycoprotein sulfation in mammalian cells, which could aid in the understanding of its functional role and potentially lead to identification of disease biomarkers.