Structural basis for assembly of non-canonical small subunits into type I-C Cascade

Roisin E. O’Brien; Inês C. Santos; Daniel Wrapp; Jack P. K. Bravo; Evan A. Schwartz; Jennifer S. Brodbelt; David W. Taylor

doi:10.1038/s41467-020-19785-8

Nature Communications (Nov 2020)

Structural basis for assembly of non-canonical small subunits into type I-C Cascade

Roisin E. O’Brien,
Inês C. Santos,
Daniel Wrapp,
Jack P. K. Bravo,
Evan A. Schwartz,
Jennifer S. Brodbelt,
David W. Taylor

Affiliations

Roisin E. O’Brien: Institute for Cell and Molecular Biology, University of Texas at Austin
Inês C. Santos: Department of Chemistry, University of Texas at Austin
Daniel Wrapp: Department of Molecular Biosciences, University of Texas at Austin
Jack P. K. Bravo: Department of Molecular Biosciences, University of Texas at Austin
Evan A. Schwartz: Institute for Cell and Molecular Biology, University of Texas at Austin
Jennifer S. Brodbelt: Department of Chemistry, University of Texas at Austin
David W. Taylor: Institute for Cell and Molecular Biology, University of Texas at Austin

DOI: https://doi.org/10.1038/s41467-020-19785-8
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 6

Abstract

Read online

Type I-C Cascade (the CRISPR-associated complex for antiviral defense) is a minimal system, comprising only three unique Cas proteins. Cryo-EM structure of the Desulfovibrio vulgaris type I-C Cascade reveals the molecular mechanisms that underlie RNA-directed complex assembly.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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