A 3D printed magnesium ammonium phosphate/polycaprolactone composite membrane for Guided bone regeneration

Yunxian Liu; Liangzhi Du; Jinghan Song; Meng Zhang; Shimin Du; Wen Long; Wen Song; Xiaofeng Chang; Zhe Li

Materials & Design (Mar 2024)

A 3D printed magnesium ammonium phosphate/polycaprolactone composite membrane for Guided bone regeneration

Yunxian Liu,
Liangzhi Du,
Jinghan Song,
Meng Zhang,
Shimin Du,
Wen Long,
Wen Song,
Xiaofeng Chang,
Zhe Li

Affiliations

Yunxian Liu: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China; Department of implant dentistry, College of Stomatology, Xi’an Jiaotong University, Xi’an, 710004, China
Liangzhi Du: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China; Department of digital oral implantology and prothodontics, College of Stomatology, Xi’an Jiaotong University, Xi’an, 710004, China
Jinghan Song: State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi’an, 710032, China
Meng Zhang: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China; Department of implant dentistry, College of Stomatology, Xi’an Jiaotong University, Xi’an, 710004, China
Shimin Du: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China; Department of implant dentistry, College of Stomatology, Xi’an Jiaotong University, Xi’an, 710004, China
Wen Long: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China; Department of implant dentistry, College of Stomatology, Xi’an Jiaotong University, Xi’an, 710004, China
Wen Song: State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi’an, 710032, China; Corresponding authors at: State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases , Shaanxi Key Laboratory of Stomatology , Department of Prosthodontics，School of Stomatology , The Fourth Military Medical University, Xi’an, 710032, China(Wen Song); Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China (Xiaofeng Chang, Zhe Li).
Xiaofeng Chang: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China; Department of implant dentistry, College of Stomatology, Xi’an Jiaotong University, Xi’an, 710004, China; Corresponding authors at: State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases , Shaanxi Key Laboratory of Stomatology , Department of Prosthodontics，School of Stomatology , The Fourth Military Medical University, Xi’an, 710032, China(Wen Song); Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China (Xiaofeng Chang, Zhe Li).
Zhe Li: Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China; Department of digital oral implantology and prothodontics, College of Stomatology, Xi’an Jiaotong University, Xi’an, 710004, China; Corresponding authors at: State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases , Shaanxi Key Laboratory of Stomatology , Department of Prosthodontics，School of Stomatology , The Fourth Military Medical University, Xi’an, 710032, China(Wen Song); Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China (Xiaofeng Chang, Zhe Li).

Journal volume & issue: Vol. 239
p. 112733

Abstract

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Guided bone regeneration (GBR) is a widely utilized technique for alveolar bone augmentation and the GBR membrane plays a crucial role in this procedure. However, developing a membrane that possesses both mechanical property and biodegradability still remains a challenge. In this study, MgNH4PO4·6H2O (MNP) and polycaprolactone (PCL) were utilized to prepare a novel MNP-PCL composite GBR membrane via 3D printing method, and five different radios of MNP were included (5, 10, 15, 20, 25 wt%). All samples were well prepared into 25 mm × 25 mm square membranes with a thickness of about 0.8 mm. The membranes exhibited promising interconnected network structure with great distribution uniformity, mechanical properties, and biodegradability. Additionally, the membranes also possessed the capacities of sustained magnesium ions release (4 weeks at least) and weakly alkaline environment maintainance (pH 8.0–––8.5), which might be beneficial for promoting bone formation, this hypothesis was then confirmed by in vitro and in vivo studies that the adhesion, proliferation, osteogenic differentiation of MC3T3-E1 and new bone formation were signicantly enhanced on 10 % and 15 % MNP-PCL surfaces. In summary, the MNP-PCL membrane may providing a new approach for the development of GBR membranes in the future.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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