Molecular and cellular basis of pathogenesis of tick-borne encephalitis

Abstract

Main features of pathogenesis of tick-borne encephalitis virus’ persistense and outcome of the disease are determined by a complex xharacter of interaction between the virus and immune system of a patient. One of the main terms of pathogenetically im- portant virus activation is a low immune resistanse of an organism. The current article discusses role of modification of cellular dif- ferentiation, intercellular cooperation and cytogenetic instability of immunocytes as well as apoptosis as leading features of immu- nopathogenesis of tick-borne encephalitis.

Keywords

• вирус клещевого энцефалита
• иммунная система
• апоптоз
• днк-репарация
• цитокины
• tick-borne encephalitis virus
• immune system
• apoptosis
• dna-reparation
• cytokines