Nature Communications (Jan 2023)

Effectiveness of mRNA-1273 vaccination against SARS-CoV-2 omicron subvariants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5

  • Hung Fu Tseng,
  • Bradley K. Ackerson,
  • Katia J. Bruxvoort,
  • Lina S. Sy,
  • Julia E. Tubert,
  • Gina S. Lee,
  • Jennifer H. Ku,
  • Ana Florea,
  • Yi Luo,
  • Sijia Qiu,
  • Soon Kyu Choi,
  • Harpreet S. Takhar,
  • Michael Aragones,
  • Yamuna D. Paila,
  • Scott Chavers,
  • Carla A. Talarico,
  • Lei Qian

DOI
https://doi.org/10.1038/s41467-023-35815-7
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 10

Abstract

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In this study, the authors estimate the effectiveness of the mRNA-1273 (Moderna) vaccine for Omicron subvariants using data from the USA on ~31,000 cases and ~92,000 matched controls. They find that effectiveness against infection waned rapidly after third and fourth doses, but effectiveness against hospitalization remained high.