Estimation of radiation dose rates' changes on Hb using dielectric parameters

Abstract

In this paper we will introduce several physical parameters that are very promising to use as indicators to diagnose and prognose tissue, cellular and molecular status. Relaxation time, DC conductivity, activation energy and enthalpy of the haemoglobin (Hb) molecule are introduced as key parameters to detect changes in the polarizability of Hb relating this change to the state of the molecule. Using dielectric and impedance measurements, we fitted the relaxation peaks found within the frequency and temperature windows to the proper equations to get our pre-mentioned parameters. Activation energy, Ea, and enthalpy change, ΔH, are also calculated. Results of higher dose rate (HDR) and lower dose rate (LDR) had different patterns for most parameters. Relaxation time and dc conductivity are sensitive to the electrical homogeneity of the Hb. Activation, E, and enthalpy change are sensitive to the damage of the Hb molecule. Early diagnosis and prognosis differentiating between higher and lower dose rates used is possible. Dielectric parameters represent promising biophysical markers for diagnosis and prognosis of radiation exposure.

Keywords

• hb relaxation time
• dc conductivity
• activation energy
• dose rate
• dielectric spectroscopy
• enthalpy