Drug Design, Development and Therapy (Mar 2021)
Antibacterial and Antimicrobial Effects of Xanthorrhizol in the Prevention of Dental Caries: A Systematic Review
Abstract
Ghulam Sarwar Khalid,1 Mohammad Hassan Hamrah,2 Elaha Somaya Ghafary,3 Sepideh Hosseini,2 Fateme Almasi2 1Department of Pharmacology, Alberoni University, Kapisa, Afghanistan; 2Department of Pediatric Dentistry, Tehran University of Medical Sciences, Tehran, Iran; 3Department of Periodontics, Kabul University of Medical Sciences, Kabul, AfghanistanCorrespondence: Elaha Somaya GhafaryDepartment of Periodontics, Kabul Medical University, Kabul, AfghanistanTel/Fax +93776665337Email [email protected]: Xanthorrhizol is one of the numerous phytochemicals whose pharmacological benefits have been explored for its antibacterial and antimicrobial effects. In light of the role bacteria play for initiating tooth decay, this present systematic review assessed xanthorrhizol’s effect against dental caries.Methods: The electronic databases including Pubmed, Scopus and Embase were searched up to September 2020, Studies examining the antibacterial and antimicrobial effects of xanthorrhizol in the prevention and treatment of dental caries.Results: Eleven studies met the criteria for final inclusion. Findings from these studies showed that xanthorrhizol showed significant inhibition of notable caries causing bacteria including Streptococcus mutans, Streptococcus sanguinis, Enterococcus faecalis and Bacillus cereus. Furthermore, there was no reported toxicity. However, it could not selectively target the growth of cariogenic bacteria.Conclusion: So far, studies exploring the use of xanthorrhizol as a potential drug for the prevention and treatment of dental caries have shown promising outcomes. However, more work needs to be done especially in areas such as optimal dose or concentration, in addition, in vitro, in vivo and clinical studies and selective targeting of cariogenic bacteria has been performed.Keywords: xanthorrhizol, antibacterial, antimicrobial, dental caries
