Pathogens (Dec 2022)

Late Diagnosis of Disseminated <i>Sporothrix brasiliensis</i> Infection with Bone Marrow Involvement in an HIV-Negative Patient

  • Vanessa Caroline Randi Magalhães,
  • Salene Angelini Colombo,
  • Gustavo José Cota Freitas,
  • Alexandre Sampaio Moura,
  • Flávia Cardoso Lopez Vieira,
  • Ana Cláudia Lyon,
  • Maria Isabel Azevedo,
  • Nalu Teixeira de Aguiar Peres,
  • Daniel Assis Santos

DOI
https://doi.org/10.3390/pathogens11121516
Journal volume & issue
Vol. 11, no. 12
p. 1516

Abstract

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Sporotrichosis is a fungal disease that causes symptoms similar to those of other infectious and non-infectious diseases, making diagnosis difficult and challenging. Here, we report a case of an HIV-negative patient presenting disseminated sporotrichosis with widespread cutaneous lesions mimicking pyoderma gangrenosum, with bone marrow infection, pancytopenia, and hemophagocytic syndrome. However, all the clinical manifestations and a bacterial coinfection delayed the request for a fungal diagnosis. Therefore, sporotrichosis should always be investigated in patients from endemic areas presenting with widespread cutaneous lesions associated with pancytopenia.

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