Influence of 3-acetyl-5-hydroxy-2-methylindole on glioma cell proliferation and metabolism

Jan U. Panada; Valeriya A. Klopava; Tatsiana A. Kulahava; Yaroslav V. Faletrov; Matvey S. Horetski; Nina S. Frolova; Siarhei V. Koran; Elena G. Fomina; Vladimir M. Shkumatov

doi:10.33581/2520-257X-2022-1-43-52

Журнал Белорусского государственного университета: Химия (Mar 2022)

Influence of 3-acetyl-5-hydroxy-2-methylindole on glioma cell proliferation and metabolism

Jan U. Panada,
Valeriya A. Klopava,
Tatsiana A. Kulahava,
Yaroslav V. Faletrov,
Matvey S. Horetski,
Nina S. Frolova,
Siarhei V. Koran,
Elena G. Fomina,
Vladimir M. Shkumatov

Affiliations

Jan U. Panada: ORCiD; Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus
Valeriya A. Klopava: Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus
Tatsiana A. Kulahava: ORCiD; Institute for Nuclear Problems, Belarusian State University, 11 Babrujskaja Street, Minsk 220006, Belarus
Yaroslav V. Faletrov: Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus; Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus
Matvey S. Horetski: ORCiD; Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus
Nina S. Frolova: Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus
Siarhei V. Koran: ORCiD; Republican Research and Practical Center for Epidemiology and Microbiology, 23 Filimonava Street, Minsk 220114, Belarus
Elena G. Fomina: ORCiD; Republican Research and Practical Center for Epidemiology and Microbiology, 23 Filimonava Street, Minsk 220114, Belarus
Vladimir M. Shkumatov: Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus b Institute for Nuclear Problems, Belarusian State University, 11 Babrujskaja Street, Minsk 220006, Belarus; Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus

DOI: https://doi.org/10.33581/2520-257X-2022-1-43-52
Journal volume & issue: no. 1
pp. 43 – 52

Abstract

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A 3-acetyl analogue of 5-hydroxyindole was synthesised and evaluated for its effects on rat C6 glioma cell functions. It was found that 3-acetyl-5-hydroxy-2-methylindole at 10 μmol/L led to a sharp reduction of mitochondrial membrane potential, induction of autophagy and decrease of proliferation of C6 glioma cells. The compound’s effect was comparable to that of rotenone, an inhibitor of cell respiration.

Published in Журнал Белорусского государственного университета: Химия

ISSN: 2520-257X (Print); 2617-3980 (Online)
Publisher: Belarusian State University
Country of publisher: Belarus
LCC subjects: Science: Chemistry
Website: https://journals.bsu.by/index.php/chemistry/index

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