Long noncoding RNA SAM promotes myoblast proliferation through stabilizing Sugt1 and facilitating kinetochore assembly

Yuying Li; Jie Yuan; Fengyuan Chen; Suyang Zhang; Yu Zhao; Xiaona Chen; Leina Lu; Liang Zhou; Ching Yan Chu; Hao Sun; Huating Wang

doi:10.1038/s41467-020-16553-6

Nature Communications (Jun 2020)

Long noncoding RNA SAM promotes myoblast proliferation through stabilizing Sugt1 and facilitating kinetochore assembly

Yuying Li,
Jie Yuan,
Fengyuan Chen,
Suyang Zhang,
Yu Zhao,
Xiaona Chen,
Leina Lu,
Liang Zhou,
Ching Yan Chu,
Hao Sun,
Huating Wang

Affiliations

Yuying Li: Department of Chemical Pathology, The Chinese University of Hong Kong
Jie Yuan: Department of Chemical Pathology, The Chinese University of Hong Kong
Fengyuan Chen: Department of Orthaepedics and Traumatology, The Chinese University of Hong Kong
Suyang Zhang: Department of Orthaepedics and Traumatology, The Chinese University of Hong Kong
Yu Zhao: Department of Orthaepedics and Traumatology, The Chinese University of Hong Kong
Xiaona Chen: Department of Orthaepedics and Traumatology, The Chinese University of Hong Kong
Leina Lu: Department of Chemical Pathology, The Chinese University of Hong Kong
Liang Zhou: Department of Toxicology, School of Public Health, Southern Medical University
Ching Yan Chu: Department of Obstetrics and Gynaecology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Hao Sun: Department of Chemical Pathology, The Chinese University of Hong Kong
Huating Wang: Department of Orthaepedics and Traumatology, The Chinese University of Hong Kong

DOI: https://doi.org/10.1038/s41467-020-16553-6
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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Long noncoding RNA SAM (Sugt1 associated muscle) is upregulated in the proliferating myoblast cells. Here the authors investigate SAM knockout mice and suggest that SAM binds and stabilizes Sugt1, a co-chaperone protein that regulates kinetochore assembly.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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