RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex

Timothy S. Catlett; Massimo M. Onesto; Alec J. McCann; Sarah K. Rempel; Jennifer Glass; David N. Franz; Timothy M. Gómez

doi:10.1038/s41467-021-22770-4

Nature Communications (May 2021)

RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex

Timothy S. Catlett,
Massimo M. Onesto,
Alec J. McCann,
Sarah K. Rempel,
Jennifer Glass,
David N. Franz,
Timothy M. Gómez

Affiliations

Timothy S. Catlett: Department of Neuroscience, University of Wisconsin School of Medicine and Public Health
Massimo M. Onesto: Department of Neuroscience, University of Wisconsin School of Medicine and Public Health
Alec J. McCann: Department of Neuroscience, University of Wisconsin School of Medicine and Public Health
Sarah K. Rempel: Department of Neuroscience, University of Wisconsin School of Medicine and Public Health
Jennifer Glass: Department of Pediatrics, Cincinnati Children’s Hospital Medical Center
David N. Franz: Department of Pediatrics, Cincinnati Children’s Hospital Medical Center
Timothy M. Gómez: Department of Neuroscience, University of Wisconsin School of Medicine and Public Health

DOI: https://doi.org/10.1038/s41467-021-22770-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

Read online

Patients with Tuberous Sclerosis Complex (TSC) show aberrant wiring of neuronal connections. Here, the authors generate iPSC-derived neurons from patients with TSC. TSC2 +/− neurons show impaired mTOR-independent RhoA signaling-mediated axon guidance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal