Impact of ImarsilTM Adsorption on Aflatoxin M1 (AFM1) Levels in Cow's Milk: Analyzing Hematological Parameters and Histopathological Alterations

Abstract

The efficacy of ImarsilTM in mitigating the effects of aflatoxin M1 (AFM1) in cow's milk on hematological and histopathological parameters was investigated in this study. Seventy-two albino rats were randomly allocated to four treatment groups A - D in a six-week study. Rats in all groups were fed standard ration. In addition, 2 mL of clean distilled water, 2 mL of milk, 2 mL of AFM1 contaminated milk (456 ng/L), and 2 mL of AFM1 contaminated milk (456 ng/L) treated with ImarsilTM at 2% dosage rate were added to the ration of animals in groups A, B, C, and D respectively. The results of the investigation showed that rats in Group C developed a significant (p0.05) among the different groups. In group C, a significant reduction (p<0.05) occurred in the white blood cell (103/mm3) (12.90 - 8.63), and lymphocytes (87.00 - 74.33%) counts while the neutrophils (%) increased from 13.00 to 25.67. In contrast to those in Group C, tissue sections from Group D showed no histological lesions. Therefore, ImarsilTM represents an effective and safe adsorbent for the remediation of AFM1-contaminated milk.

Keywords

• adsorbents
• aflatoxin m1
• cow’s milk
• hematological parameters and histopathological changes
• imarsiltm