Journal of the International Association of Providers of AIDS Care (Jul 2017)

Cholecalciferol 20 000 IU Once Weekly in HIV-Positive Patients with Low Vitamin D Levels: Result from a Cohort Study

  • Sebastian Noe MD,
  • Silke Heldwein MD,
  • Rita Pascucchi MD,
  • Celia Oldenbüttel MD, PhD,
  • C. Wiese MD,
  • Ariane von Krosigk MD,
  • Eva Jägel-Guedes MD,
  • Hans Jäger MD,
  • Wolfgang Mayer MD,
  • Christoph D. Spinner MD,
  • Eva Wolf PhD

DOI
https://doi.org/10.1177/2325957417702487
Journal volume & issue
Vol. 16

Abstract

Read online

Purpose: To evaluate efficacy and safety of 20 000 IU cholecalciferol weekly in HIV-infected patients. Methods: Longitudinal data for 243 HIV-infected patients with paired 25-OH-vitamin D3 values for the same month in 2 consecutive years were stratified by the initiation of supplementation in this retrospective study. Results: After 1 year of administration of cholecalciferol 20 000 IU weekly, about 78% of patients with initial vitamin D level 20 µg/L and 42% achieved levels >30 µg/L. Supplemented patients with baseline vitamin D levels <20 µg/L showed a significant risk reduction for hypocalcemia ( P = .006; risk difference: 20.8%) and a significantly lower increase in alkaline phosphatase (AP) compared to those in the nonsubstituted group. Conclusion: The dose of 20 000 IU of cholecalciferol once weekly was found to be safe and effective. Normalization of vitamin D levels within 1 year was observed in 42% to 75% of the patients.